Medscape8 天
Role of CXCR4 in HIV Infection and its Potential as a Therapeutic Target
The bicyclam AMD3100 is a well-known small molecule CXCR4 antagonist that strongly and specifically inhibits X4 HIV-1 infection. Tetrahydroquinoline-based AMD070 is a potent and specific X4 HIV-1 ...
来自MSN1 个月
Q&A: Improving liver cancer outcomes through enhanced immunotherapy
This study tested the effect of specifically blocking CXCR4 on standard anti-PD1 immunotherapy in liver cancer models. Most previous studies and clinical trials tested AMD3100, a small-molecule ...