Effects of COX-2-selective NSAIDs on Vascular Endothelium: Class or Individual Effect? To date, the mechanism of increased cardiovascular risk associated with COX-2-selective NSAIDs remains ...

[77] Intuitively, the combination of a COX-2-selective NSAID plus a proton pump inhibitor (PPI) should provide effective analgesia and further decrease the risk of upper-GI events compared to a ...

Following the withdrawal of rofecoxib and valdecoxib, the discussion concerning selective cyclo-oxygenase ... a further differentiation of COX-2 inhibitors and NSAIDs in terms of cardiovascular ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?