Effects of COX-2-selective NSAIDs on Vascular Endothelium: Class or Individual Effect? To date, the mechanism of increased cardiovascular risk associated with COX-2-selective NSAIDs remains ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

The review of recent developments emphasizes the need for novel selective COX-2 inhibitors that possess improved safety profiles compared to existing NSAIDs, which have been linked to various ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

The FDA approved an oral combination of meloxicam and rizatriptan (Symbravo) to treat adults with acute migraine with or ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

Meloxicam is also a selective COX-2 inhibitor, reducing the risk of GI side effects compared to naproxen. However, NSAIDs ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?

[77] Intuitively, the combination of a COX-2-selective NSAID plus a proton pump inhibitor (PPI) should provide effective analgesia and further decrease the risk of upper-GI events compared to a ...