Effects of COX-2-selective NSAIDs on Vascular Endothelium: Class or Individual Effect? To date, the mechanism of increased cardiovascular risk associated with COX-2-selective NSAIDs remains ...

Background: We investigated the potential interactions between esomeprazole and a non-selective nonsteroidal anti-inflammatory drug (NSAID; naproxen) or a cyclo-oxygenase (COX)-2-selective NSAID ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

NSAIDs are the principal agents used for managing pain in patients with chronically painful diseases, such as osteoarthritis. However, the withdrawal of the selective cyclo-oxygenase 2 (COX2 ...

It differs from non-selective NSAIDs because it targets the COX-2 enzyme, primarily involved in inflammation. Celebrex works ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?