4). Protease digestion or heat treatment abrogated the chemokinetic activity of BMCM, and pretreating T cells with pertussis toxin or antibody against CXCR4 caused an inhibition of bi-directional ...

为了回答这一问题，科学家们在一个专门开发的3D组织培养模型中将人类动脉粥样硬化斑块与来自同一患者机体的CD8 + T细胞在一起培养，结果发现，增加的CD8 + ...

Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and ...

"This did indeed lead to a significant reduction in CD8 + T cell migration into atherosclerosis plaques," affirms Duchêne, "suggesting that the CXCL12–CXCR4 signaling pathway plays a key role ...

"This did indeed lead to a significant reduction in CD8+ T cell migration into atherosclerosis plaques," affirms Duchêne, "suggesting that the CXCL12-CXCR4 signaling pathway plays a key role in ...