Cardiac hypertrophy is an adaptive or maladaptive response to stress caused by changes in pressure or volume, which results in an increase in cardiomyocyte size. Cardiac hypertrophy can be classified ...

In humans, heart injury leads to the formation of scar tissue and cardiomyocyte hypertrophy, but the heart does not regenerate. In the December 13 Science, Kenneth Poss and colleagues, at Harvard ...

Targeted genomic approaches (such as gene knockout/knockdown) can then be carried out in an iPSC-derived cardiomyocyte model of hypertrophy to better define the roles of individual factors in cardiac ...

In particular, we are interested in two cell types: cardiomyocytes, i.e. heart muscle cells, and vascular endothelial cells, and we aim to find ways to promote cardiomyocyte renewal after a myocardial ...