Important insights into the mechanisms behind Fuchs endothelial corneal dystrophy (FECD), a common cause of age-related visual loss, have been revealed in a new study led by UCL researchers.

or atopic keratoconjunctivitis (AKC), the mechanisms are more complex and probably involve both IgE and T-cell-mediated responses. Only the last two diseases develop corneal complications (Table 1).

HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

The corneal endothelium showed a beaten bronze appearance without corneal edema (Figure 1b). The left fundus showed significant retinal venous tortuosity with an otherwise normal retina and a ...

At the same time, keratic precipitates (Fig. 1A) were seen in 12 eyes as discrete hyperreflective spots attached to the cornea endothelium, and fibrinous membrane (Fig. 1B) were detected in 4 eyes ...