The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...
Hosted on MSN29d
DNA hydrogels show promise for sustained drug releaseHowever, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.
ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...
However, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.
Hosted on MSN14d
Takumi-shaped DNA hydrogels show promise for targeted therapiesHowever, current methods like DNA ligase-linked hydrogels present many challenges, including potential allergic reactions and complex administration procedures that limit clinical applications.
Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced ... makes Mdm2 a better or worse ligase remains a puzzle to be solved.
During the DNA damage response (DDR), repair proteins such as the E3 ubiquitin ligase BRCA1 accumulate at DNA double-stranded breaks (DSBs), and ubiquitylation at these sites helps recruit further ...
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