There are 8 to 10 slices in a large Domino's pizza, although that will vary depending on the crust, with the largest going up to 16 slices in the Extra Large New York style.
While the number may vary, a medium Domino's pizza typically has between 6 to 8 slices.
At Domino's, it's not just sides and drinks that are different. The largest pizza size in the US — an extra-large — is 2.5 inches bigger than the largest pizza size in the UK — a large pizza.