Certain skin problems can indicate disease. During a gout flare-up, the skin over the ankle joint area is often a bright red.

To further explore the consequences of IL-1 blockade, the investigators developed a new acute gout model by use of intra-articular injection of MSU crystals into the ankle joint of mice.

During an acute attack of gout, inflammatory mediators are released and vascular adhesion and chemotaxis of leukocytes to the inflamed joint is enhanced. 7 However, for this to have an impact on ...

Gout can be extremely painful and can affect other joints including the ankle, fingers, elbows, wrists and knees. The patient with gout often has redness and signs of inflammation such as heat ...