The detailed sequence of events following ECM binding to the integrin is not known ... FAK appears to localize to nascent focal adhesions because it binds to paxillin. Upon activation, FAK ...

“When we remove Cas from cells, or inhibit its phosphorylation, or inhibit stuff downstream of Cas, the integrin clustering doesn’t ... of very well known biochemical proteins in the focal adhesions, ...

Integrin cytoplasmic tyrosine motif is required ... Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proceedings of the National ...

Contrary to what the terms cytoskeleton and focal adhesion suggest ... that paxillin binds directly to the intracellular part of integrin. It clings to the receptor, so to speak.