The detailed sequence of events following ECM binding to the integrin is not known ... FAK appears to localize to nascent focal adhesions because it binds to paxillin. Upon activation, FAK ...

the integrin clustering doesn’t really happen,” Cooper said. The Cas-depleted cells attached poorly to surfaces and were immobile. "It really nicely revealed all the sequence and dependence of very ...

Contrary to what the terms cytoskeleton and focal adhesion suggest ... that paxillin binds directly to the intracellular part of integrin. It clings to the receptor, so to speak.