Transform the verified clones into the cell lines of interest to test their ability to knock down gene expression. The vector(s) may be transiently transfected into any commonly used cell line ...

A new method for elucidating gene function in mammals was discovered in 2000; it uses small double-stranded RNAs to interfere with gene expression ... accepted as gene-knockout tools.

1 Scientists have harnessed RNAi in the laboratory to selectively silence target gene expression, a technique known as gene knockdown ... 9 Functional genomics researchers now commonly use RNAi to ...

Both gene knockout and knock-in models are powerful ... latter of which is associated with superior efficacy in knocking down ...

The technique: A specific short peptide aimed at fat cells can deliver a DNA sequence that knocks down expression of a key fatty acid binding protein ... functions of adipocytes—a notoriously ...

Qure (QURE) announced that the Independent Data Monitoring Committee for EPISOD1, uniQure’s Phase I/II clinical trial of AMT-162, an ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...