1 There are three different macrophage types, naïve (M0), antitumor (M1), and protumor (M2). M1 macrophages accumulate at the tumor and exert antitumor activity. Researchers have attempted to use them ...

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.

Early diagnosis is crucial in disease prevention and treatment. Many diseases can be identified not just through physical ...

A recent study showed that paracrine delivery of miR-21a-5p by bone marrow mesenchymal stem cells-derived apoptotic bodies ...

Researchers focused particularly on the role of M1 and M2 macrophages in the tumor microenvironment. Macrophages are immune ...

Dr. Ram Murali, VP of Research and Development stated, “KROS 401 is designed to reverse the M1 to M2 transition of macrophages in the tumor microenviroment. What this translates to is changing ...

activating nearby antigen presenting cells (APCs), notably dendritic cells (DCs), and repolarizing tumor-associated macrophages (TAMs) toward an M1 phenotype. In addition to direct phagocytosis of ...

Interestingly, this study noted an increase in the proportion of M1 macrophages and a decrease in M2 macrophages in CRC, contradicting the M1/M2 polarization theory. Functional analyses suggests ...