Mechanistic studies showed that Lrrk2 promotes macrophage polarization toward the M1 phenotype by enhancing STAT1 phosphorylation in response to IFN-γ signaling. This function is dependent on the ...

The study detailed that an imbalance in macrophage polarization is linked to the progression of autoimmune and autoinflammatory diseases, including rheumatoid arthritis and systemic lupus ...

In essence, this strategy turns limitations, often considered weaknesses, into strengths. For example, in their 2021 Cell Reports study on macrophage polarization mechanisms, dermatologist Alexander ...

More information: Emilia Bianchini et al, The Role of Hyaluronan/Receptor for Hyaluronan-Mediated Motility Interactions in ...