Dihydroergotamine (DHE) is an ergotamine analog (Figure 3). DHE is administered as a nasal spray form (Migranal®, Valeant Pharmaceuticals, QC, Canada) or by injection. Ergotamine (Ergomar ...

It is sold under brand names such as Migranal, Trudhesa, and D.H.E 45, where administration is via nasal spray or injection.

which got the go-ahead from the FDA for its Trudhesa nasal spray product in 2021, and Bausch Health’s well-established Migranal brand, which has been on the market since the late 1990s.