Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death.

Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the body's immune response through modulating specific cell signaling ...

When they detect the presence of RNA viruses, they activate interferons through the mitochondrial antiviral signaling (MAVS) pathway. The MAVS protein resides on the outer membrane of a cell's ...