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Nature:80岁大脑重返20岁?0.54微米防护网成抗衰老新靶点
但希望之光已然显现:研究者通过腺相关病毒(AAV)基因治疗,将衰老小鼠脑血管的糖萼厚度恢复83%,不仅逆转血管渗漏,更让20月龄老年鼠在迷宫测试中展现超越年轻组的空间记忆能力。这项颠覆性发现不仅重新定义了血脑屏障的防御机制,更为对抗阿尔茨海默病开辟了全新治疗维度:修复纳米级的糖萼结构,或将成为阻止大脑"塌方式衰老"的关键突破口。
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