Prions represent a new class of infectious agents which propagate on a protein-only level, not requiring agent-encoded nucleic acids. Newly emergent prion diseases such as bovine spongiform ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent.

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment ...

these compounds could be re-purposed for treatment of prion diseases," said corresponding author David A. Harris, MD, PhD, ...

Although these results are promising, additional research from the Benjamin Deverman lab at the Broad Institute took CHARM one step closer to clinical trials by designing an AAV vector that can make ...

Jan. 14, 2025 — Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

This includes developing a pioneering technique that detects toxic build ups of prion protein in the spinal fluid. This means that researchers will be able to identify at-risk people early and when ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60%.

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...