Prion protein may play key role in progression of glioblastoma
Glioblastoma (GBM), one of the most aggressive types of brain cancer, is one of the greatest challenges for medicine, both ...
New test distinguishes between prion disease and other causes of rapidly progressive dementia
Mayo Clinic launched a new prion test, RT-QuIC Prion, CSF, which can distinguish prion disease from other causes of rapidly ...
Nature3 个月
Staining, straining and restraining prions
Prions, the causative agents of transmissible spongiform encephalopathies, appear to consist entirely of PrP Sc, an orderly aggregated, β sheet–rich isoform of a ubiquitous membrane protein ...
BioWorld19 天
Broad Institute advances gene therapy for prion disease
Led by a team at the Broad Institute, the new gene therapy aims to address the root cause of prion disease by using the CHARM (Coupled Histone tail for Autoinhibition Release of Methyltransferase) ...
Nature1 个月
More than just mad cow disease
The development of treatment strategies will rely on results from two main areas: (i) efforts to identify infected but asymptomatic individuals, and (ii) research to understand prion biology ...
ZME Science on MSN6 小时
The Other Terrifying Deer Disease Creeping Across the US
Across North America, deer and elk are increasingly suffering from a devastating illness. They stumble, drool, and appear visibly emaciated. They lose their fear of humans, staring blankly as if their ...
The Economist25 天
Epigenetic editors are a gentler form of gene editing
They now run a lab at the Broad Institute in Boston. By 2024 they had created an editor that, in mice, turns off the prion gene in the brain, preventing the disease from taking hold. Next up is making ...
Science Daily1 年
Mad Cow Disease News
Jan. 14, 2025 — Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.
The Scientist6 个月
Understanding Neurodegenerative Disease with Prion Research
Prion diseases are characterized by abnormal folding of the host’s naturally-occurring ... such as alleviating suffering by improving the understanding, prevention, and treatment of illnesses. “She ...
Case Western Reserve University2 年
NPDPSC Autopsy Coordination Program
An autopsy helps to further our understanding of prion disease, add to its detection and hopefully will lead to a successful treatment of this disease. In order to reach that goal, we must first ...
Case Western Reserve University4 年
About the NPDPSC
The center is supported by the CDC and sponsored by the American Association of Neuropathologists. The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in ...