Immune dysfunction during chronic infections and cancer leads to disease progression due to T cell exhaustion. In this process, CD8 + T cells fail to form functional memory. T cell exhaustion results ...

The study showed that T-cells expressing the cell receptor CD38 were more susceptible to exhaustion. Using an anti-CD38 antibody, the research team was able to block CD38 and overcome T-cell ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its ...

Having established success in cancer, biopharma is now looking to leverage CAR T therapies against a new target, autoimmune ...

To investigate the mechanisms behind CTL exhaustion, Chang and his team grafted melanoma tumors onto mice. As the tumors grew, the researchers observed fewer T cells and a reduction in cytokine levels ...

It develops from the abnormal multiplication of T cells, or T-lymphocytes, a type of white blood cell essential for immune system function. The specific treatment course and prognosis for T-cell ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...