Recently, research efforts have focused on using NGS to quantify the number of mutations in cancer cells (the tumour mutational burden — TMB) and to identify genetic patterns that impair DNA ...

That's because these patients are more likely than those of other ancestries to carry a molecular signature called high tumor mutation burden (TMB-H) in solid tumors. More recently, several drugs ...

values of 0.503 and 0.543 for tumor mutational burden (TMB). For predicting clinical benefit (tumor response or prolonged stability), SCORPIO demonstrated superior predictive performance ...

In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

The company’s broad panel NGS assays can also be used to highlight the tumor mutational burden (TMB), homologous recombination deficiency status (HDR), and microsatellite instability (MSI ...

The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven ...

In a video interview, William K. Oh, MD, director of precision medicine at Yale Cancer Center and Smilow Cancer Hospital discusses the latest breakthroughs in advanced prostate cancer treatment.

Nelmastobart (hSTC810) combined with capecitabine therapy in metastatic colorectal cancer with resistance or intolerance to oxaliplatin and irinotecan-based chemotherapy: A phase 1b clinical trial.

Despite recent advances in therapy, certain subtypes of colorectal cancer, such as those that are microsatellite instability ...