"Furthermore, as evidenced by increased Evans blue staining and decreased VE-cadherin levels, the BBB exhibited dysfunction in ADM2 knockout mice with anxiety-like behaviors." Overall, the ...

These properties led Lee and colleagues to investigate cadherin molecule functioning in synovial lining and in autoimmune arthritis. Initial investigations in healthy mice demonstrated that ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...