Background Biological ageing is one of the principal risk factors for neurodegenerative diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as measured by the ...

1 Institute of Brain and Behavior, Department of Psychiatry, University of Maastricht, Maastricht, The Netherlands 2 Department of Radiology, Academisch Ziekenhuis Maastricht, Maastricht, The ...

Objective: Parkinson’s disease (PD) is a progressive neurological disorder characterised by a large number of motor and non-motor features that can impact on function to a variable degree. This review ...

1 Department of Neurology, Westmead Hospital and Western Clinical School, University of Sydney, Sydney, Australia 2 Prince of Wales Medical Research Institute and Prince of Wales Clinical School, ...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting the upper and lower motor neurons. A key clinical feature of ALS is the absence of accurate, early-stage ...

Objectives We aimed to compare the long-term outcomes and surgical benefits between moyamoya disease (MMD) and atherosclerosis-associated moyamoya vasculopathy (AS-MMV) using high-resolution MRI ...

Background GBA variants increase the risk of developing Parkinson disease (PD) and influence its outcome. Deep brain stimulation (DBS) is a recognised therapeutic option for advanced PD. Data on DBS ...

Background and purpose Cerebral amyloid angiopathy (CAA) is common in the ageing brain and is associated with dementia and lobar intracerebral haemorrhage. We systematically reviewed genetic ...

Correspondence to Dr Timothy Rittman, Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building, Forvie Site, Addenbrooke's Hospital Site, Robinson Way, Cambridge CB2 0SZ, ...

Correspondence to: Dr Peter Henningsen, Department of Psychosomatic Medicine, University Hospital, Thibautstr 2, 69115 Heidelberg, Germany; peter_henningsen{at}med.uni-heidelberg.de Objective: To ...