GENFI Top Hits. CSF proteomics linked abundance of CALB2, GRN/NAGA, and PEA15/SEMA6A to C9ORF72 (gold), GRN (red), and MAPT ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

Enter SynPull, a new synaptosome imaging method developed by David Klenerman, John Danial, and colleagues at the University of Cambridge, England. SynPull combines single-molecule pull-down of ...

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The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

Unknown. Multiple in silico algorithms yielded conflicting results.

SORL1 knockout, knockin, and transgenic mice are now in the Research Models database. The database will be updated as more models become available.

The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 1970's, ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...

Families with early\ onset Alzheimer disease (eFAD) are an isolated group dispersed all over the world. See Interview: A Spouse's Perspective on Clinical Trials for eFAD. Part of their problem is that ...

reactive to aa 1-16 of Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms ...