Paramount's Novocaine made $1.75 million in previews and the R-rated action comedy might lead the box office this weekend with anywhere from $8M-$12M,

This weekend’s films earned a total of $51 million across the board, per Box Office Mojo—the lowest-grossing weekend of 2025 to date. That’s even lower than the weekend of the Super Bowl, which is typically a quiet time,

“Novocaine” only cost $18 million to produce, so (like its main character) it shouldn’t be feeling any pain at the box office. On the flip side, “Mickey 17” cost $118 million to produce and needs around $275 million to $300 million worldwide to make a profit.