Background Synaptosomal-associated protein 25 (SNAP-25) in cerebrospinal fluid (CSF) is an emerging synaptic biomarker for the early diagnosis of Alzheimer’s disease (AD). However, comprehensive ...

1 Department of Neurology, St George’s University Hospitals NHS Foundation Trust, London, UK 2 Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s, ...

University of Iowa, The Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA Objective: The objective of the Predict-HD study is to use genetic, neurobiological and refined clinical ...

Department of Neurological Surgery Chiba University School of Medicine, 1–8–1 Inohana, Chuoh-ku, Chiba-shi, Chiba Japan 260–8670 Naokatsu Saeki, MD, Department of Neurological Surgery, Chiba ...

Leukodystrophy is a diverse range of conditions that involve dysmeylination and demyelition. 10%–25% of adult onset leukodystrophy are related to mutations of the CSF1R gene. The clinical phenotype ...

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Correspondence to Dr Timothy Rittman, Department of Clinical Neurosciences, University of Cambridge, Herchel Smith Building, Forvie Site, Addenbrooke's Hospital Site, Robinson Way, Cambridge CB2 0SZ, ...

The National Hospital for Neurology and Neurosurgery, Queen Square and the Reta Lila Weston Institute of Neurological Studies, UCL, London, UK Correspondence to Professor Andrew Lees, Reta Lila Weston ...

Background Tai Chi has shown beneficial effects on the motor and non-motor symptoms of Parkinson’s disease (PD), but no study has reported the effect of long-term Tai Chi training. Objective To ...

Antimyelin-associated glycoprotein (MAG) neuropathy is a rare autoimmune demyelinating peripheral neuropathy caused by IgM autoantibodies targeting MAG. The typical presentation is that of a slowly ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Background Subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson’s disease (PD) improves quality of life (QoL), motor and non-motor symptoms (NMS). However, in previous studies, 43%–49% ...