and that the sequelae of acromegaly are serious enough to justify the currently available expensive treatments. However, the definition of 'normal concentrations' is not straightforward.

The mean age at diagnosis is 40-50 years and the most common cause is a GH-secreting pituitary adenoma. A majority (nearly 75%) of patients with acromegaly will have a pituitary macroadenoma (>10 mm) ...

examined the long term (≤18 years) antihormonal and antitumor efficacy as well as the safety of somatostatin analogs in 36 patients (mean age 53 years) with acromegaly. Patients received ...