An AI model named ESM3 was developed to simulate 500 million years of evolution, generating a novel fluorescent protein. Trained on extensive protein data, ESM3 mimics evolutionary processes to ...

A team of AI researchers, biologists and evolutionary ... More information: Thomas Hayes et al, Simulating 500 million years of evolution with a language model, Science (2025).

Scientists Found a Paradox in Evolution—and It May Become the Next ... “ESM3 takes a step toward a future of biology where AI is a tool to engineer from first principles, the way we engineer ...

with a genetic sequence so different from known fluorescent proteins that the researchers say its creation is equivalent to ESM3 simulating 500 million years of biological evolution. The model cou ...