In addition, type I IFNs affect macrophage functions by enhancing their tumoricidal and phagocytic capacities and shaping a tumor-suppressive tumor microenvironment (TME), which is characterized by ...

Io Biotech Aps has presented preclinical data regarding their Arg1-derived peptide cancer vaccine IO-112 as a potential immunotherapeutic that would allow controlling the tumor microenvironment.

Macrophages represent one of the most prevalent cells in the colorectal cancer microenvironment and play a pivotal role in maintaining intestinal health and the development of colitis-associated colon ...

This study provides useful information by identifying the cell type (macrophages) in synovial tissues involved in the pathogenesis of post-traumatic osteoarthritis (OA) and clarifying distinct ...

This led the researchers to another question: why would glucose metabolism and lactate accumulation cause ARG1 to be expressed? With a better understanding of neutrophil reprogramming, the researchers ...

Males with pulmonary arterial hypertension (PAH) have more proinflammatory macrophages — a type of immune cell — in the lungs than do females with the disease, a study suggests. Researchers identified ...

When exposed to various stimuli, monocytes/macrophages are recruited to and retained within the local tissue microenvironment, where they can activate and display either proinflammatory or ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Division of Evolution, Infection & Genomic Sciences, University of Manchester, Manchester M13 9PL, U.K. Division of Evolution, Infection & Genomic Sciences ...