Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

An important factor in referring to NSAIDs as 'COX-2 selective inhibitors' or 'COX nonselective inhibitors' is that 'selective' inhibition by NSAIDs is referred to at the level of the COX proteins ...

Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

Celebrex (celecoxib) is a selective NSAID. It differs from non-selective NSAIDs because it targets the COX-2 enzyme, ...

Medically reviewed by David Ozeri, MD Prescription anti-inflammatory medications are used to reduce pain, inflammation, and ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

NSAIDs are the principal agents used for managing pain in patients with chronically painful diseases, such as osteoarthritis. However, the withdrawal of the selective cyclo-oxygenase 2 (COX2 ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?