为探究 FOLR2 + 巨噬细胞在乳腺癌（BRCA）中的作用，研究人员经多技术联用，发现其经 CXCL9-CXCR3 轴激活 CD8 + T 细胞，提供新治疗方向。 在女性健康领域，乳腺癌（Breast Cancer，BRCA）一直是个 “大麻烦”。近年来，乳腺癌的发病率和死亡率呈上升趋势，严重威胁着 ...

1Duke University, Durham, NC.

Further experimental research found that when human—derived aortic smooth muscle cells are stimulated by interferon—γ, knocking down the RSAD2 gene will lead to a decrease in the expression and ...

Delivery of indole-3-acetic acid by tumor-colonizing bacteria changes the tumor microenvironment in a murine model, significantly increasing levels of CXCL9 and IFN-γ and elevating tumor-infiltrating ...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, ...

2 Department of Rheumatology and Clinical Immunology, Semmelweis University, Budapest, Hungary 4 Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary 5 Heart and ...

This study describes the impact of mycobacterial genetic diversity on host-infection phenotypes by assessing the effect of different M. tuberculosis lineages on granulomatous inflammation using a 3D ...

在这样的背景下，浙江大学医学院附属邵逸夫医院等多家机构的研究人员展开了深入研究。他们将目光聚焦于白细胞介素 - 16（IL-16），这是一种此前研究较少的细胞因子，其在肿瘤免疫中的作用一直不为人知。研究人员通过一系列实验，发现 IL-16 在建立 Th1 细胞介导的抗肿瘤免疫微环境中发挥着关键作用，相关成果发表在《Nature Communications》上。

This is an important study that provides CCR7-APEX2 proximity labelling mass spectrometry data that is expected to provide new insights into CCR7 signaling partners and pathways. The study is ...

Clinical and Radiographic Outcomes of Four Different Treatment Strategies in Patients With Early Rheumatoid Arthritis (the Best Study): A Randomized, Controlled Trialfrom Arthritis & Rheumatism ...