Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4—which together with CD4 mediate virus binding and membrane fusion 3. As CCR5, but not CXCR4 ...

Importantly, the interaction between CXCR4 and its ligand SDF-1 is involved in various disease conditions, such as cancer cell metastasis, leukemia cell proliferation, rheumatoid arthritis and ...

"This did indeed lead to a significant reduction in CD8 + T cell migration into atherosclerosis plaques," affirms Duchêne, ...