C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic ...

We often take facts we learn — like the fact that transcription factors bind to DNA — for granted. Or maybe not. See how researchers used DNA footprinting and gel shift assays to prove this idea.

The team initially set out to study another replication machinery protein, single-stranded DNA-binding protein, and its interaction with DNA polymerase. However, they first needed to establish how the ...

This DNA-binding protein was previously known to have played a role in controlling gene expression but how this happens was unclear. To figure this out they teamed up with leading experts from Madrid, ...

“Our hypothesis is that strand slippage, or stutter, is caused by slippage of the DNA against the DNA polymerase that it's binding to, and that's performing the polymerization,” said David Mokry, a ...

RNase H is an enzyme involved in genome maintenance, and breaks down RNA in RNA/DNA hybrids in the motor. The slower RNase H binding occurs, the longer the pauses in motion, which is what leads to ...