"Our findings reveal for the first time that glycolysis-derived H3K14 lactylation (H3K14la) plays a key role in endothelial dysfunction by regulating the transcription of ferroptosis-related genes ...

Endothelial dysfunction is one manifestation of the many changes induced in the arterial wall by the metabolic abnormalities accompanying diabetes and insulin resistance. In type 1 diabetes ...

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Single-cell RNA sequencing also revealed that specific cell types, such as endothelial cells and macrophages, exhibited higher senescence-related gene expression after PAGln treatment. In the ...

Concurrently, aging is an inevitable and complex phenomenon characterized by a variety of factors, including genomic instability, telomere shortening, epigenetic modifications, mitochondrial ...

The primary node molecules in the cell signaling network in cancer tissues are maladjusted and mutated in comparison to normal tissues, which promotes the occurrence and progression of cancer.

Mechanosensitive Piezo1 channel plays a key role in pulmonary hypertension (PH). However, the role of Piezo2 in PH remains unclear.

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Conclusions FBXW7 is a key factor in the association between mechanical overloading and chondrocyte senescence and cartilage ageing in the pathology of OA. HZ, YS and ZY contributed equally.