Sarah Vine and Andrew Pierce bring their own no-holds-barred opinions, insights and reaction (clue is in the title) to the biggest stories of the week. New episodes every Wednesday, wherever you ...

Inspired by the reformist passion of figures such as William Morris and John Ruskin, the Arts and Crafts movement had a huge effect on Victorian society. Its advocates looked to history and to the ...

As an additional means of meeting these targets, the Kyoto Protocol introduced three market-based mechanisms, thereby creating what is now known as the carbon market. Stimulate sustainable development ...

The most commonly mutated ALS-linked genes are reviewed with an emphasis on disease-causing mechanisms. The cellular processes involved in ALS pathogenesis are discussed, with evidence implicating ...

The subsequent cascade of enzymatic reactions is tightly regulated to assure that complement is activated only ... of the complement pathways and their implication on physiology and pathology. This ...

A change is called irreversible if it cannot be changed back again. Many chemical reactions are irreversible. In a chemical reaction, new materials are always formed. Sometimes these new materials ...

ORF3a, an accessory protein of SARS-CoV-2, mediates the transmembrane transport of water, leading to lysosome swelling. This function could, in principle, result in lysosome inactivation, a ...

pH is a measure of how acidic or alkaline a solution is. The diagram below shows what happens to an enzyme when denaturation occurs. Each enzyme has an optimum pH but it also has a working range ...