Study reveals B cells suppress mutations during rapid division, enhancing immune response and offering critical insights for ...

在我们的生活中，免疫系统扮演着至关重要的角色。它不仅帮助我们抵御外来病原体的侵袭，还能记住曾经遇到过的病原体，从而在再次感染时迅速做出反应。这种免疫记忆力，主要由记忆B细胞（Memory B Cells, MBCs）承担。然而，记忆B细胞是如何形成的？这一过程背后的分子机制一直是一个未解之谜。

1. 《Nature》杂志发表了一项突破性研究，揭示了免疫细胞在生发中心中的"突变刹车"技术，使优质B细胞能在分裂过程中保持基因稳定性。 3. 通过荧光示踪技术，研究人员捕捉到细胞周期的"快进键"：优质B细胞的DNA复制速度提升2.3倍，让诱变酶 ...

因此，IL-9-ZBTB18 信号轴指导了生发中心中功能性 B 细胞记忆的形成。这些发现破解了 B 细胞 免疫 记忆形成的关键分子机制，为通过操控免疫记忆而强化疫苗、创新免疫治疗提供了新靶点。

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells scramble to refine their defenses, rapidly mutating ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

A vaccine's ability to generate long-lasting, high-affinity antibodies hinges on a delicate balance. Upon exposure to a vaccine or pathogen, B cells ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and ...

Successful high-affinity B cells can proliferate under special conditions that reduce the risk of mutation. Capturing this ...