文章研究表明，表观药物Panobinostat和Tazemetostat的组合可以通过对肿瘤细胞的组蛋白修饰重编程，抑制与肿瘤进展相关的基因表达。通过HiTIP-seq技术，研究人员对来自DMG患者肿瘤干细胞的表观修饰改变进行了深入分析，揭示了这两种 ...

Diffuse midline glioma (DMG), H3K27-altered, is a lethal pediatric high-grade tumor, lacking effective treatment options, ...

《Acta Neuropathologica Communications》：Curative timed NK cell-based immunochemotherapy aborts brain tumour recurrence driven by mesenchymal glioma stem cells ...