Due to this risk, your doctor may suggest you stop taking the melatonin supplement if you’re prescribed Spravato. Or, they may recommend you don’t use the melatonin supplement on days when you ...

Spravato was first approved for use in 2019 to treat people with major depressive disorder who did not respond to at least two other antidepressants. Under that approval, patients had to take an ...

Earlier this month, NICE reiterated its position that Spravato should not be used for TRD, after an appeal of earlier rejections by J&J, with a final decision due in mid-December. In the ESCAPE ...

Spravato (esketamine) has become the first standalone therapy to be cleared by the US regulator for adult patients with treatment-resistant depression (TRD), extending its 2019 approval for use in ...