Verastem Oncology , a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, announced today multiple oral and poster presentations at the ...

In the present review, we focus on the cellular mechanical response through ECM-integrin-cytoskeleton-nucleus axis and critically discuss the molecular basis of focal adhesion cell mechanosensing. We ...

assemble focal adhesions and display tissue phenotypes characteristic of MECs interacting with a stiff matrix. Such observations underscore the importance of integrin signalling and Rho-dependent ...

School of Power and Mechanical Engineering, The Institute of Technological Science, Wuhan University, Wuhan 430072, China Nanotechnology Center, School of Fashion and Textiles, The Hong Kong ...

University of Maribor, Faculty of Mechanical Engineering, Laboratory for Characterisation and Processing of Polymers, Smetanova ulica17, 2000 Maribor, Slovenia Members of the European Polysaccharide ...

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated compartments where cells sense environmental cues. The physical mechanisms and molecular interactions that mediate ...

Intracellular syndecan domains activate signaling with PKCα (P) and via binding to PDZ-motif proteins. Integrin activation recruits a host of focal adhesion components, including integrin-binding ...

We find that TGFβ receptors are discretely organized to segregated spatial domains at the cell surface. Integrin-rich focal adhesions organize TβRII around TβRI, limiting the integration of TβRII ...

1–3 Rat aortic rings were incubated with Texas red-conjugated heparin probes, embedded in tissue freezing medium and frozen. Aortic ring slices were labeled with anti-M 3 and/or anti-α 5 integrin and ...