NK cell production takes place in the Netherlands ... and killer cell immunoglobulin-like receptor (KIR) is not necessary with oNKord. “If you have to match on HLA and KIR, you need a large ...

Overview of current approaches to improve effectiveness of adoptive transfer of NK cells by manipulation of the NK cell product, the host and the target. Human NK cells are a subset of peripheral ...

ILT: Immunoglobulin-like transcript; KIR: Killer cell immunoglobulin-like receptor; LIR: Leukocyte immunoglobulin-like receptor; MIC: MHC class I-like; NKR: Natural killer cell receptor; ULBP ...

The polymorphic nature of KIRs and their ligands adds a layer of complexity to NK cell interactions with tumor cells. Moreover, other inhibitory receptors like CD94/NKG2A, PD-1, TIGIT, and TIM-3 ...

The presence of HLA class I molecules, which interact with inhibitory KIRs on NK cells to limit their ... an E3 ubiquitin protein ligase, inhibits NK cell cytolytic activity and thereby improves ...