Hence, with combined and simultaneous signalling from different receptors, each NK cell can balance and calibrate an appropriate response. KIR is highly polymorphic; an individual’s KIR configuration ...

Overview of current approaches to improve effectiveness of adoptive transfer of NK cells by manipulation of the NK cell product, the host and the target. Human NK cells are a subset of peripheral ...

Other techniques like blocking the human leukocyte antigen-killer cell receptors (KIR) interactions with anti-KIR monoclonal antibodies, preventing CD16 receptor shedding, increasing the expression of ...

ILT: Immunoglobulin-like transcript; KIR: Killer cell immunoglobulin-like receptor; LIR: Leukocyte immunoglobulin-like receptor; MIC: MHC class I-like; NKR: Natural killer cell receptor; ULBP ...

Imatinib mesylate, a protein tyrosine kinase inhibitor, can induce caspase-independent death of tumour cells, can enhance natural killer (NK)-cell activities and can induce the expansion of a ...

Gilead Sciences' cell therapy Kite Pharma has bulked up its position in natural killer (NK) cell therapies, pledging up to $2.3 billion for a partnership with Shoreline Bioscience focusing on off ...

Jan. 23, 2025 — There's a downside to being a powerful alpha male -- at least if you're a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice. The ...

30 SynKIR-110, developed by Verismo Therapeutics, is another innovative CAR-T cell therapy targeting MSLN-expressing tumors. Using the KIR-CAR platform, this therapy enhances the persistence and ...

This valuable manuscript presents a thorough analysis of the evolution of Major Histocompatibility Complex gene families across Primates. A key strength of this analysis is the use of state-of-the-art ...