Overview of current approaches to improve effectiveness of adoptive transfer of NK cells by manipulation of the NK cell product, the host and the target. Human NK cells are a subset of peripheral ...
ILT: Immunoglobulin-like transcript; KIR: Killer cell immunoglobulin-like receptor; LIR: Leukocyte immunoglobulin-like receptor; MIC: MHC class I-like; NKR: Natural killer cell receptor; ULBP ...
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Targeting intracellular checkpoints to enhance NK cell immunotherapyThe polymorphic nature of KIRs and their ligands adds a layer of complexity to NK cell interactions with tumor cells. Moreover, other inhibitory receptors like CD94/NKG2A, PD-1, TIGIT, and TIM-3 ...
The presence of HLA class I molecules, which interact with inhibitory KIRs on NK cells to limit their ... an E3 ubiquitin protein ligase, inhibits NK cell cytolytic activity and thereby improves ...
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