1 There are three different macrophage types, naïve (M0), antitumor (M1), and protumor (M2). M1 macrophages accumulate at the tumor and exert antitumor activity. Researchers have attempted to use them ...

Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer-related deaths worldwide.

Circadian rhythms are endogenous time-keeping mechanisms that regulate physiological processes in response to external ...

Early diagnosis is crucial in disease prevention and treatment. Many diseases can be identified not just through physical ...

Researchers focused particularly on the role of M1 and M2 macrophages in the tumor microenvironment. Macrophages are immune ...

Dr. Ram Murali, VP of Research and Development stated, “KROS 401 is designed to reverse the M1 to M2 transition of macrophages in the tumor microenviroment. What this translates to is changing ...

This means that macrophages do not simply switch between the canonical two states previously described; instead, they can ...

Interestingly, this study noted an increase in the proportion of M1 macrophages and a decrease in M2 macrophages in CRC, contradicting the M1/M2 polarization theory. Functional analyses suggests ...