This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Using genome-wide meta-analyses of clinical measures of depression and biobank data, the authors investigate symptom-specific genetic associations between depression and subsequent risk for ...

Uncertainty: one-way sensitivity and threshold analysis ICER: genotype directed dosing dominates usual care. Genotyping cost CDN$663 and usual care CDN$677 per patient. Uncertainty: one-way ...

2016). The produced Fshr-ZsGreen (Fshr-ZsG) knockin mice were maintained as heterozygotes, and homozygotes were used for experiments. For genotyping, genomic DNA was extracted from tail tips and ...

Uncertainty: one-way sensitivity and threshold analysis ICER: genotype directed dosing dominates usual care. Genotyping cost CDN$663 and usual care CDN$677 per patient. NNT for genotyping was 20 ...