Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial ...

When the researchers activated a ROS-dependent signaling pathway, IL-10 production was restored in the mice, even with defective mitochondrial complexes. This finding highlights how mitochondrial ...

Objective Accumulation of mitochondria underlies T-cell dysfunction in systemic lupus erythematosus (SLE). Mitochondrial turnover involves endosomal traffic regulated by HRES-1/Rab4, a small GTPase ...

最近的研究发现ECSIT在非免疫细胞和免疫细胞中对肿瘤发生有重要影响。肠道上皮细胞中ECSIT的缺失引起线粒体功能损伤并促进代谢重编程，谷氨酸代谢增加引起α-酮戊二酸/琥珀酸比率升高，进而促进TET去甲基化酶激活并诱导选择性翻译起始因子eIF4A1/ ...