as a critical regulator for intra- and extra-cellular redox signaling, involved in the pathogenesis of various diseases such as cancer, autoimmune disease, and diabetes. Box 1. Localization of Trx and ...

There is increasing evidence that key oncogenes and tumor suppressors modulate mitochondrial dynamics through important signaling pathways and that mitochondrial mass and ... including nutrient ...

Mechanistically, PGRN deficiency suppressed mitochondrial respiration, induced mitochondrial fission, and disturbed autophagy process and redox signaling, while restoration of PGRN levels in aortae ...

Many proteins of the mitochondrial intermembrane space are small and contain characteristic Cys motifs. Most of these proteins are imported and folded by the redox-dependent mitochondrial ...

Redox biology is a field that studies the role ... particularly in relation to mitochondrial activity, neuronal health, and cardiovascular function. In the context of neurodegenerative diseases ...

Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ ...

State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China ...

Scientists in Dr. Navdeep Chandel’s laboratory at Northwestern University have uncovered how mitochondria help regulate the immune system by influencing key cell signaling pathways. Their study, ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes ...

Cugell, MD, Professor of Medicine in the Division of Pulmonary and Critical Care, have discovered how mitochondria influence the body's immune response through modulating specific cell signaling ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial ...