Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to ...

Graphical Abstract. Hypothetical mechanisms of mitophagy dysfunction in POLG-mutant astrocytes. Nicotinamide riboside was provided by Evandro Fei Fang (University of Oslo, Norway). The cells were ...

最近的研究发现ECSIT在非免疫细胞和免疫细胞中对肿瘤发生有重要影响。肠道上皮细胞中ECSIT的缺失引起线粒体功能损伤并促进代谢重编程，谷氨酸代谢增加引起α-酮戊二酸/琥珀酸比率升高，进而促进TET去甲基化酶激活并诱导选择性翻译起始因子eIF4A1/ ...

Saudi Arabia’s billion-dollar-a-year healthspan initiative, the Hevolution Foundation, has unveiled a sweeping portfolio of ...

As researchers continue to draw varying conclusions on the most effective weight management strategy, a revolutionary formula ...

Jan. 14, 2025 — There may be a link between hearing impairment and an increased risk of developing Parkinson's according to new research. This is one of the first studies to examine whether ...

Metabolic disorders occur when the body's usual metabolic processes are disrupted. These diseases can be congenital or acquired, for example, diabetes and phenylketonuria.