Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to ...

Graphical Abstract. Hypothetical mechanisms of mitophagy dysfunction in POLG-mutant astrocytes. Nicotinamide riboside was provided by Evandro Fei Fang (University of Oslo, Norway). The cells were ...

最近的研究发现ECSIT在非免疫细胞和免疫细胞中对肿瘤发生有重要影响。肠道上皮细胞中ECSIT的缺失引起线粒体功能损伤并促进代谢重编程，谷氨酸代谢增加引起α-酮戊二酸/琥珀酸比率升高，进而促进TET去甲基化酶激活并诱导选择性翻译起始因子eIF4A1/ ...

State Key Laboratory of Crystal Materials, Department of Otolaryngology-Head and Neck Surgery, Shandong Institute of Otorhinolaryngology, Shandong Provincial ENT Hospital, Shandong University, Jinan, ...

Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China ...

A specially designed drug prevented laboratory mice from developing heart failure after heart attacks, according to new research from Cedars-Sinai. This discovery could lead to new treatments to ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

Researchers at Cedars-Sinai developed PR-364, a drug that prevented heart failure in mice after heart attacks. The treatment ...

Saudi Arabia’s billion-dollar-a-year healthspan initiative, the Hevolution Foundation, has unveiled a sweeping portfolio of ...

As researchers continue to draw varying conclusions on the most effective weight management strategy, a revolutionary formula ...