Adult human hearts possess limited regenerative abilities, so losing cardiomyocytes (CMs) after injury can result in contractile dysfunction and heart failure. In contrast, neonatal mammalian hearts ...

Methods HBECs from non-smokers (n=5), smokers (n=12) and patients with COPD (n=15) were collected to measure the mesenchymal markers α-smooth muscle actin, vimentin and collagen type I and the ...

EMB 促进 GBM 细胞侵袭和迁移的机制 ：研究人员利用 Transwell 实验和伤口愈合实验发现，敲低 EMB 可降低 GBM 细胞的侵袭和迁移能力，而过表达 EMB 则会增强这些能力。进一步研究发现，EMB 可通过激活上皮 - 间质转化（Epithelial-mesenchymal transition，EMT）通路，上调间质标记物 N - 钙粘蛋白（N-cadherin，N-CAD）水平 ...

研究结论和讨论部分意义重大。研究表明 CENPF 在胶质瘤中显著上调且与预后不良相关，它作为癌基因，通过激活 mTORC1 信号通路和诱导 EMT 过程促进胶质瘤的恶性表型。CENPF 与 PLA2G4A 相互作用，调节 mTORC1 和 NF-κB ...

The journal Advanced Materials recently published a study introducing a new method for monitoring molecular processes deep ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...

Segmentation of the vertebrate body is first established during embryogenesis by the periodic formation of pairs of somites — for example, every 120 minutes in mouse, 90 minutes in chicken and ...

Aadi Bioscience, Inc. , an oncology therapeutics company applying advanced technologies to established tumor biology to efficiently deliver advances in cancer treatment, today announced that the ...

Translational research in the cardiovascular field is hampered by the unavailability of cardiac models that can recapitulate organ-level physiology of the myocardium. Outside the body, cardiac tissue ...