Adult human hearts possess limited regenerative abilities, so losing cardiomyocytes (CMs) after injury can result in contractile dysfunction and heart failure. In contrast, neonatal mammalian hearts ...

BACKGROUND: Lymphedema is an incurable disease associated with lymphatic dysfunction that causes tissue swelling and fibrosis ...

A novel mouse model offers definitive evidence that a single inhibitory receptor family governs the critical natural killer cell functions of licensing and missing-self.

Methods HBECs from non-smokers (n=5), smokers (n=12) and patients with COPD (n=15) were collected to measure the mesenchymal markers α-smooth muscle actin, vimentin and collagen type I and the ...

EMB 促进 GBM 细胞侵袭和迁移的机制 ：研究人员利用 Transwell 实验和伤口愈合实验发现，敲低 EMB 可降低 GBM 细胞的侵袭和迁移能力，而过表达 EMB 则会增强这些能力。进一步研究发现，EMB 可通过激活上皮 - 间质转化（Epithelial-mesenchymal transition，EMT）通路，上调间质标记物 N - 钙粘蛋白（N-cadherin，N-CAD）水平 ...

研究结论和讨论部分意义重大。研究表明 CENPF 在胶质瘤中显著上调且与预后不良相关，它作为癌基因，通过激活 mTORC1 信号通路和诱导 EMT 过程促进胶质瘤的恶性表型。CENPF 与 PLA2G4A 相互作用，调节 mTORC1 和 NF-κB ...

The journal Advanced Materials recently published a study introducing a new method for monitoring molecular processes deep ...

targeting cadherin-17 (CDH17). The data highlight SOT109's promising activity and tolerability profile across multiple disease models, reinforcing its potential to become a best-in-class ...

Segmentation of the vertebrate body is first established during embryogenesis by the periodic formation of pairs of somites — for example, every 120 minutes in mouse, 90 minutes in chicken and ...

Aadi Bioscience, Inc. , an oncology therapeutics company applying advanced technologies to established tumor biology to efficiently deliver advances in cancer treatment, today announced that the ...